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New Tenofovir Prodrug Is Noninferior to Currently Used Prodrug

Published Tuesday March 14

Whole new N. – Antiretroviral combinations containing the recently approved tenofovir alafenamide prodrug offer similar effectiveness and tolerability to those of combinations containing tenofovir disoproxil fumarate, according to 2 noninferiority trials.

This provides randomized clinical trial safety and efficacy data for physicians to guide their decision in switching to

Odefsey” Drive Huyen Cao from Gilead Sciences, Foster City, Calif. told Reuters WHO by email.

Tenofovir plasma concentrations are 90% lower with tenofovir alafenamide than with tenofovir disoproxil fumarate, so the risks of renal and bone toxicity are expected to be lower.

Article length: About 280 words.
Tags: Foster City
Read more at Rxlist

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